High lymphoid enhancer-binding factor-1 expression is associated with disease progression and poor prognosis in chronic lymphocytic leukemia

We determined lymphoid enhancer-binding factor-1 (LEF1) mRNA expression in 112 chronic lymphocytic leukemia (CLL) samples and assessed correlations with the prognostic markers ZAP70 and CD38, Binet stages, the percentage of lymphocytes in the peripheral blood, and fibromodulin (FMOD) transcripts. Th...

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Published in:Hematology reports 2010-05, Vol.2 (1), p.e3-e3
Main Authors: Erdfelder, Felix, Hertweck, Magdalena, Filipovich, Alexandra, Uhrmacher, Sabrina, Kreuzer, Karl-Anton
Format: Article
Language:English
Subjects:
CD38 antigen
Chronic lymphocytic leukemia
Gene expression
Leukemia
Lymphatic leukemia
Lymphocytes
lymphoid enhancer-binding factor-1 (LEF1), Chronic Lymphocytic Leukemia (CLL), Zeta-Associated Protein (ZAP70), CD38, fibromodulin
Peripheral blood
Prognosis
Risk assessment
ZAP-70 protein
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Summary:We determined lymphoid enhancer-binding factor-1 (LEF1) mRNA expression in 112 chronic lymphocytic leukemia (CLL) samples and assessed correlations with the prognostic markers ZAP70 and CD38, Binet stages, the percentage of lymphocytes in the peripheral blood, and fibromodulin (FMOD) transcripts. The mean LEF1 relative expression ratios (RER) were 53.72 and 37.10 in ZAP70-positive and ZAP70-negative patients, respectively (P=0.004). However, we did not observe a significant difference in LEF1 expression between CD38-positive and CD38-negative patients. Moreover, patients requiring treatment showed a mean LEF1 RER of 85.61 whereas patients in recently diagnosed Binet A stage had a mean of only 22.01 (P
ISSN:2038-8330
2038-8322
2038-8330
DOI:10.4081/hr.2010.e3