Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

• Published in: Cancer medicine (Malden, MA) MA), 2019-08, Vol.8 (10), p.4722-4731
• Main Authors: Xu, Jiasheng, Guo, Jingjing, Jiang, Yangkai, Liu, Yujun, Liao, Kaili, Fu, Zhonghua, Xiong, Zhenfang
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Apoptosis; Biomarkers; Biomarkers, Tumor - genetics; Breast cancer; Cancer Biology; Carcinogenesis; Cell cycle; Cell growth; Cell proliferation; Chemoresistance; Chromosome 19; Clear cell-type renal cell carcinoma; Colorectal cancer; Colorectal carcinoma; Digestive system; Disease Progression; Drug Resistance, Neoplasm; Epigenetics; Esophagus; Gallbladder cancer; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genomes; Hepatocellular carcinoma; Humans; Kidney cancer; Kinases; linc00152; Liver cancer; long non‐coding RNA; Lung cancer; Lymphatic system; malignant tumor; Medical prognosis; Metastases; Metastasis; Neoplasms - genetics; Neoplasms - pathology; Notch1 protein; Nucleotides; Prognosis; Proteins; Review; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; Signal transduction; Stem cells; Therapeutic applications; TOR protein; Tumorigenesis; Tumors
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.2245

Linc00152, located on chromosome 2p11.2, is a long intergenic non‐coding RNA molecule with 828 nucleotides that is highly expressed in many types of human tumor tissues, especially in malignant tumors of the digestive system. Linc00152 promotes the occurrence and development of tumors by increasing tumor cell proliferation, invasion, metastasis, and apoptosis. Additionally, linc00152 contributes to the carcinogenesis of several cancers, including gastric cancer, liver cancer, hepatocellular carcinoma, gallbladder cancer, clear cell renal cell carcinoma, and colorectal cancer, by disturbing various signaling pathways (eg PI3K/AKT, mTOR, IL‐1, and NOTCH 1 signaling pathways). High linc00152 expression levels are associated with chemoresistance as well as poor prognosis and shorter survival. Continual advances made in the relevant research have indicated that linc00152 may be useful as a new tumor molecular biomarker, applicable for tumor diagnosis, targeted therapy, and prognosis assessment. This review summarizes the progress in the research into the relationship between linc00152 and the occurrence and development of malignancies based on molecular functions, regulatory mechanisms, and clinical applications. This review summarizes the progress in the research into the relationship between linc00152 and the occurrence and development of malignancies based on molecular functions, regulatory mechanisms, and clinical applications.