Pharmacological and toxicological investigations of etodolac loaded gum katira microspheres prepared by W1/O/W2 emulsion solvent evaporation technique in rats

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) and approved by USFDA as a COX2 inhibitor. Although etodolac therapy provides clinical benefits, it is associated with upper gastrointestinal (GI) tract complications also. Etodolac loaded gum Katira microsphere (ELGKM) was prepared by W1/O/...

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Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences 2017-01, Vol.53 (4)
Main Authors: Ruhidas, Biswajit, Ray, Rajat, Naskar, Debjyoti, Chakra, Biplab Kumar, Chatterjee, Tapan Kumar
Format: Article
Language:English
Subjects:
Animals
Bioavailability
Etodolac/inflammatory conditions
Etodolac/physicochemical characterization
Experiments
Gum Katira/microspheres
Laboratories
Osteoarthritis
Pain therapy
Patient compliance
PHARMACOLOGY & PHARMACY
Plasma
Polyvinyl alcohol
Proteins
Reagents
Rheumatoid arthritis
Solvents
Stomach
Ulcers
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Summary:Etodolac is a non-steroidal anti-inflammatory drug (NSAID) and approved by USFDA as a COX2 inhibitor. Although etodolac therapy provides clinical benefits, it is associated with upper gastrointestinal (GI) tract complications also. Etodolac loaded gum Katira microsphere (ELGKM) was prepared by W1/O/W2 emulsion solvent evaporation technique. The gastric irritation properties of orally administered pure etodolac, ELGKM and blank microspheres (without etodolac) were evaluated in experimental rats treated for 6 days. The stomach examination and biochemical investigation of stomach tissue of treated rats indicated that ELGKM formulation remarkably reduced ulcerogenecity as compared to pure etodolac. The anti-inflammatory activities of pure etodolac and ELGKMs were ascertained by the implantation of cotton pellets in rats for 6 days. Based on the results, ELGKMs showed significant anti-inflammatory activities (P
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902017000400212