Cell-Based Therapies for Heart Failure

Heart failure has reached epidemic proportions with the advances in cardiovascular therapies for ischemic heart diseases and the progressive aging of the world population. Efficient pharmacological therapies are available for treating heart failure, but unfortunately, even with optimized therapy, pr...

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Bibliographic Details
Published in:Frontiers in pharmacology 2021-04, Vol.12, p.641116-641116
Main Authors: Campos de Carvalho, Antonio Carlos, Kasai-Brunswick, Tais H, Bastos Carvalho, Adriana
Format: Article
Language:English
Subjects:
adult stem cells
bone marrow cells
cell therapies
heart failure
Pharmacology
pluripotent cells (Min5–Max 8)
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Summary:Heart failure has reached epidemic proportions with the advances in cardiovascular therapies for ischemic heart diseases and the progressive aging of the world population. Efficient pharmacological therapies are available for treating heart failure, but unfortunately, even with optimized therapy, prognosis is often poor. Their last therapeutic option is, therefore, a heart transplantation with limited organ supply and complications related to immunosuppression. In this setting, cell therapies have emerged as an alternative. Many clinical trials have now been performed using different cell types and injection routes. In this perspective, we will analyze the results of such trials and discuss future perspectives for cell therapies as an efficacious treatment of heart failure.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.641116