Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold

Regenerative endodontic procedures have gained momentum as a treatment modality of young immature permanent teeth. Literature reports reveal that platelet-rich fibrin (PRF) stimulates growth factors and induces regeneration. This study was undertaken to assess the regenerative potential of non-vital...

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Bibliographic Details
Published in:Scientific reports 2021-07, Vol.11 (1), p.13679-13679, Article 13679
Main Authors: Kritika, Selvakumar, Sujatha, V., Srinivasan, N., Renganathan, Senthil Kumar, Mahalaxmi, Sekar
Format: Article
Language:English
Subjects:
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Age groups
Antibiotics
Blood clots
Blood platelets
Cohort analysis
Dentin
Dentistry
Disinfection
Endodontics
Fibrin
Growth factors
Humanities and Social Sciences
Incisors
Maxilla
multidisciplinary
Patients
Platelets
Root canals
Science
Science (multidisciplinary)
Teeth
Trauma
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Summary:Regenerative endodontic procedures have gained momentum as a treatment modality of young immature permanent teeth. Literature reports reveal that platelet-rich fibrin (PRF) stimulates growth factors and induces regeneration. This study was undertaken to assess the regenerative potential of non-vital immature permanent maxillary central incisors using PRF with a follow-up for 2 yrs. 19 patients in the age group of 9–25 yrs with immature, non-vital permanent maxillary central incisors (n = 23) with/without signs and/or symptoms of periapical pathosis and open apex were included in this study. In the first appointment, access opening, canal disinfection and triple antibiotic paste placement were done. In the subsequent visit, PRF was prepared and placed inside the canal. Access was sealed with Mineral trioxide aggregate plug and composite. The patient was reviewed up to 24 mths. The mean difference was statistically analyzed using Friedman test followed by Dunn post hoc test and adjusted by Bonferroni correction ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-93236-2