New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri

Six new cembranoids, cherbonolides A-E ( ⁻ ) and bischerbolide peroxide ( ), along with one known cembranoid, isosarcophine ( ), were isolated from the Formosan soft coral . The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound was discov...

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Bibliographic Details
Published in:Marine drugs 2018-08, Vol.16 (8), p.276
Main Authors: Peng, Chia-Chi, Huang, Chiung-Yao, Ahmed, Atallah F, Hwang, Tsong-Long, Dai, Chang-Feng, Sheu, Jyh-Horng
Format: Article
Language:English
Subjects:
Animals
Anions
Anthozoa - chemistry
anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
biscembranoid peroxide
Cell Line, Tumor
cembranoid
Corals
Cytochalasin B
Cytochalasin B - pharmacology
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Elastase
elastase release inhibition
Formyl peptides
Humans
Leukocytes (neutrophilic)
Molecular Structure
N-Formylmethionine Leucyl-Phenylalanine - pharmacology
Neutrophils - drug effects
Neutrophils - metabolism
Neutrophils - secretion
Organic chemistry
Pancreatic Elastase - secretion
Peroxide
Peroxides - chemistry
Peroxides - isolation & purification
Peroxides - pharmacology
Phenylalanine
Sarcophyton
Sarcophyton cherbonnieri
Superoxide
Superoxide anions
Superoxides - metabolism
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Summary:Six new cembranoids, cherbonolides A-E ( ⁻ ) and bischerbolide peroxide ( ), along with one known cembranoid, isosarcophine ( ), were isolated from the Formosan soft coral . The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds ⁻ were shown to have the ability of inhibiting the production of superoxide anions and elastase release in -formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLF/CB)-induced human neutrophils.
ISSN:1660-3397
1660-3397
DOI:10.3390/md16080276