Cytokines profile in patients with hydatidosis in Babylon Province, Iraq

• Published in: Medical Journal of Babylon 2023-01, Vol.20 (1), p.212-214
• Main Authors: Al-Mosawi, Ahmed, Al-Joborae, Fadhil, Al-Joborae, Huda, Al-Saadi, Mohammed, Al-Charrakh, Alaa
• Format: Article
• Language: English
• Subjects: Care and treatment; cd4; cd8; Cytokines; Diagnosis; Health aspects; hydatidosis infection; il-6; inf-i; Parasitic diseases
• ISSN: 1812-156X; 2312-6760
• DOI: 10.4103/MJBL.MJBL_305_22

Background: Hydatidosis is caused by infection with the larval stage of the Cestode Echinococcus granulosus. Objective: In vitro quantitative evaluation of interleukin 6 (IL-6), INF-gamma (INF-γ), and CD4 and CD8 molecules during hydatidosis infection and control group. Materials and Methods: In vitro quantitative determination of IL-6, INF-γ, and CD4 and CD8 molecules in serum of hydatidosis-infected patients using serological test Sandwich-ELISA. Results: The result showed a significant difference in serum IL-6 in patients with hydatidosis than in the control group (38.753 ± 18.307 pg/mL) and 11.752 ± 3.328, respectively; the differences were highly significant (P < 0.0001). The mean of serum CD4 molecules concentration was 5.475 ± 2.335 (ng/mL) and 3.154 ± 1.027 (ng/mL) for controls groups with P value ≤ 0.0001, while serum concentration of soluble CD8 was 2.977 ± 1.321 (ng/mL) and 1.152 ± 0.699 (ng/mL) for control group with (P value ≤ 0.0001). The ratio of CD4/CD8 was 1.841 in hydatidosis infection patients compared with control group (2.737). Conclusion: Immunological parameters included in the present study (IL-6, IFN-γ, CD4 and CD8) showed high levels among patients with hydatidosis infection compared to healthy control.