Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats

Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia (BPH) has not been well understood. Hence, this study aimed to investigate the regulation of BPH on gut microbiota composition and metabonomics. We analyzed gut samples from...

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Bibliographic Details
Published in:Military medical research 2022-03, Vol.9 (1), p.12-12, Article 12
Main Authors: Li, Lu-Yao, Han, Jie, Wu, Lan, Fang, Cheng, Li, Wei-Guang, Gu, Jia-Min, Deng, Tong, Qin, Chang-Jiang, Nie, Jia-Yan, Zeng, Xian-Tao
Format: Article
Language:English
Subjects:
Animals
Benign prostatic hyperplasia
Chromatography
Chromatography, Liquid
Diabetes
Discriminant analysis
Feces
Feces - microbiology
Gastrointestinal Microbiome
Genital diseases
Gut microbiota
Hyperplasia
Intestinal metabolites
Laboratory animals
Male
Metabolomics - methods
Microbial diversity
Microbiota
Prostate
Prostatic Hyperplasia
Rats
Software
Tandem Mass Spectrometry
Testosterone - analysis
Urination
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Summary:Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia (BPH) has not been well understood. Hence, this study aimed to investigate the regulation of BPH on gut microbiota composition and metabonomics. We analyzed gut samples from rats with BPH and healthy control rats, the gut microbiota composition and metabonomics were detected by 16S rDNA sequencing and liquid chromatography tandem mass spectrometry (LC-MS/MS). High-throughput sequencing results showed that gut microbiota beta-diversity increased (P 
ISSN:2054-9369
2095-7467
2054-9369
DOI:10.1186/s40779-022-00373-4