Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women

The most representative indicator of vitamin D status in clinical practice is 25(OH)D , but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VM...

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Bibliographic Details
Published in:Nutrients 2021-10, Vol.13 (11), p.3747
Main Authors: Toribio, María José, Priego-Capote, Feliciano, Pérez-Gómez, Beatriz, Fernández de Larrea-Baz, Nerea, Ruiz-Moreno, Emma, Castelló, Adela, Lucas, Pilar, Sierra, María Ángeles, Pino, Marina Nieves, Martínez-Cortés, Mercedes, Luque de Castro, María Dolores, Lope, Virginia, Pollán, Marina
Format: Article
Language:English
Subjects:
1,25(OH)2D3
24,25(OH)2D3
25(OH)D3
Adult
Breast cancer
Calciferol
Calcitriol
Chromatography
Epidemiology
Female
Gynecology
Humans
Hydroxylase
Metabolism
Metabolites
Metabolome
Middle Aged
Premenopause - blood
Questionnaires
Regression analysis
Skin
Sociodemographics
Values
Vit D3
Vitamin D
Vitamin D - blood
vitamin D metabolite ratios
Vitamin deficiency
Womens health
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Summary:The most representative indicator of vitamin D status in clinical practice is 25(OH)D , but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH) D /25(OH)D ) and a higher R4 (24,25(OH) D /1,25(OH) D ) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D /Vit D ) and R3 (24,25(OH) D /25(OH)D ), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13113747