Sonochemotherapy: from bench to bedside

The combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects. For drug delivery, microbubble-assisted ultrasound is used to increase vascular- and...

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Bibliographic Details
Published in:Frontiers in pharmacology 2015-07, Vol.6, p.138-138
Main Authors: Lammertink, Bart H A, Bos, Clemens, Deckers, Roel, Storm, Gert, Moonen, Chrit T W, Escoffre, Jean-Michel
Format: Article
Language:English
Subjects:
Chemotherapeutic drug
Drug delivery
Life Sciences
Microbubble
Pharmaceutical sciences
Pharmaceutics
Pharmacology
sonoporation
ultrasound
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Summary:The combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects. For drug delivery, microbubble-assisted ultrasound is used to increase vascular- and plasma membrane permeability for facilitating drug extravasation and the cellular uptake of drugs in the treated region, respectively. In the case of drug-loaded microbubbles, these two mechanisms can be combined with local release of the drug following destruction of the microbubble. The use of microbubble-assisted ultrasound to deliver chemotherapeutic agents is also referred to as sonochemotherapy. In this review, the basic principles of sonochemotherapy are discussed, including aspects such as the type of (drug-loaded) microbubbles used, the routes of administration used in vivo, ultrasound devices and parameters, treatment schedules and safety issues. Finally, the clinical translation of sonochemotherapy is discussed, including the first clinical study using sonochemotherapy.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2015.00138