The NF-κB Nucleolar Stress Response Pathway

The nuclear organelle, the nucleolus, plays a critical role in stress response and the regulation of cellular homeostasis. P53 as a downstream effector of nucleolar stress is well defined. However, new data suggests that NF-κB also acts downstream of nucleolar stress to regulate cell growth and deat...

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Bibliographic Details
Published in:Biomedicines 2021-08, Vol.9 (9), p.1082
Main Authors: Thoms, Hazel C., Stark, Lesley A.
Format: Article
Language:English
Subjects:
Apoptosis
Aspirin
Biosynthesis
Cancer therapies
Cell cycle
Cell death
Cell growth
Cellular stress response
Colon cancer
DNA-directed RNA polymerase
Gene expression
Homeostasis
Hypoxia
Inflammation
Kinases
NF-κB
NF-κB protein
NPM
Nucleoli
nucleolus
nucleophosmin
p62
Proteins
Review
Ribosomal DNA
RNA polymerase
Signal transduction
Transcription factors
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Summary:The nuclear organelle, the nucleolus, plays a critical role in stress response and the regulation of cellular homeostasis. P53 as a downstream effector of nucleolar stress is well defined. However, new data suggests that NF-κB also acts downstream of nucleolar stress to regulate cell growth and death. In this review, we will provide insight into the NF-κB nucleolar stress response pathway. We will discuss apoptosis mediated by nucleolar sequestration of RelA and new data demonstrating a role for p62 (sequestosome (SQSTM1)) in this process. We will also discuss activation of NF-κB signalling by degradation of the RNA polymerase I (PolI) complex component, transcription initiation factor-IA (TIF-IA (RRN3)), and contexts where TIF-IA-NF-κB signalling may be important. Finally, we will discuss how this pathway is targeted by aspirin to mediate apoptosis of colon cancer cells.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9091082