Natural products in the management of neurodegenerative diseases

Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of mortality. Natural derivatives are more efficacious in various preclinical models of neurodegenerative illnesses. These natural compounds include phytocon...

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Published in:Nutrition & metabolism 2024-05, Vol.21 (1), p.26-26, Article 26
Main Authors: Goyal, Rajat, Mittal, Pooja, Gautam, Rupesh K, Kamal, Mohammad Amjad, Perveen, Asma, Garg, Vandana, Alexiou, Athanasios, Saboor, Muhammad, Haque, Shafiul, Farhana, Aisha, Papadakis, Marios, Ashraf, Ghulam Md
Format: Article
Language:English
Subjects:
B cells
Degeneration
Derivatives (Financial instruments)
Fresh water
Health aspects
Identification and classification
Medical colleges
Medical research
Medicine, Botanic
Medicine, Experimental
Medicine, Herbal
Nanotechnology
Natural products
Natural resources
Nervous system
Neurodegenerative diseases
Neuroinflammation
Oxidative stress
Review
Citations: Items that this one cites
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Summary:Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of mortality. Natural derivatives are more efficacious in various preclinical models of neurodegenerative illnesses. These natural compounds include phytoconstituents in herbs, vegetables, fruits, nuts, and marine and freshwater flora, with remarkable efficacy in mitigating neurodegeneration and enhancing cognitive abilities in preclinical models. According to the latest research, the therapeutic activity of natural substances can be increased by adding phytoconstituents in nanocarriers such as nanoparticles, nanogels, and nanostructured lipid carriers. They can enhance the stability and specificity of the bioactive compounds to a more considerable extent. Nanotechnology can also provide targeting, enhancing their specificity to the respective site of action. In light of these findings, this article discusses the biological and therapeutic potential of natural products and their bioactive derivatives to exert neuroprotective effects and some clinical studies assessing their translational potential to treat neurodegenerative disorders.
ISSN:1743-7075
1743-7075
DOI:10.1186/s12986-024-00800-4