Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when its p...

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Published in:Pharmaceutics 2024-01, Vol.16 (2), p.177
Main Authors: Dourado, Douglas, Miranda, Júlio Abreu, de Oliveira, Matheus Cardoso, Freire, Danielle Teixeira, Xavier-Júnior, Francisco Humberto, Paredes-Gamero, Edgar Julian, Alencar, Éverton do Nascimento
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Apoptosis
Biocompatibility
Cancer
Cancer therapies
Care and treatment
Cell cycle
Chemical elements
curcuminoids
Gold
Health aspects
Ligands
Metals
Nanoparticles
nanotechnology
oncology
Particle size
Permeability
Polyphenols
pre-clinical
Review
Toxicity
Tumors
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Summary:Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when its physicochemical properties compromise its pharmacological potential. As a therapeutic strategy against cancer, curcumin has been associated with inorganic nanoparticles. These nanocarriers are capable of delivering curcumin and offering physicochemical properties that synergistically enhance anticancer properties. This review highlights the different types of curcumin-based inorganic nanoparticles and discusses their physicochemical properties and in vivo anticancer activity in different models of cancer.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16020177