Campomanesia adamantium (Myrtaceae) fruits protect HEPG2 cells against carbon tetrachloride-induced toxicity

(Myrtaceae) is an antioxidant compounds-rich Brazilian fruit popularly known as . In view of this, it was evaluated the hepatoprotective effects of pulp (GPE) or peel/seed (GPSE) hydroalcoholic extracts of on injured liver-derived HepG2 cells by CCl (4 mM). The results showed the presence of total p...

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Bibliographic Details
Published in:Toxicology reports 2015-01, Vol.2 (C), p.184-193
Main Authors: de Oliveira Fernandes, Thaís, de Ávila, Renato Ivan, de Moura, Soraia Santana, de Almeida Ribeiro, Gerlon, Naves, Maria Margareth Veloso, Valadares, Marize Campos
Format: Article
Language:English
Subjects:
Campomanesia adamantium (Myrtaceae)
Carbon tetrachloride
Flavonoids
Hepatoprotection
HepG2 cells
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Summary:(Myrtaceae) is an antioxidant compounds-rich Brazilian fruit popularly known as . In view of this, it was evaluated the hepatoprotective effects of pulp (GPE) or peel/seed (GPSE) hydroalcoholic extracts of on injured liver-derived HepG2 cells by CCl (4 mM). The results showed the presence of total phenolic in GPSE was (60%) higher when compared to GPE, associated with interesting antioxidant activity using DPPH• assay. Additionally, HPLC chromatograms and thin layer chromatography of GPE and GPSE showed the presence of flavonoids. Pretreatment of HepG2 cells with GPE or GPSE (both at 800-1000 μg/mL) significantly (  
ISSN:2214-7500
2214-7500
DOI:10.1016/j.toxrep.2014.11.018