Effect of the uncoupling protein-2 (UCP-2) and nuclear receptor subfamily 3 group C member 1 (NR3C1) genes on treatment efficacy and survival in patients with multiple myeloma: a single-center study

• Published in: BMC research notes 2021-09, Vol.14 (1), p.346-346, Article 346
• Main Authors: Demir, Ilknur, Pehlivan, Sacide, Okan, Vahap, Sahin, Handan Haydaroglu, Durusoy, Salih Sertaç, Serin, Istemi, Oyaci, Yasemin, Pehlivan, Mustafa
• Format: Article
• Language: English
• Subjects: Alleles; Autografts; Autologous stem cell transplantation; Cancer; Dehydrogenases; Gene expression; Gene Frequency; Gene polymorphism; Genetic engineering; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Hematopoietic Stem Cell Transplantation; Humans; Lymphocytes; Medical prognosis; Mitochondrial uncoupling protein 2; Mortality; Multiple myeloma; Multiple Myeloma - genetics; Multiple Myeloma - therapy; Multivariate analysis; NR3C1; Overall survival; Oxidative stress; Patients; Polymorphism, Single Nucleotide; Prognosis; Prospective Studies; Proteins; Receptors, Glucocorticoid - genetics; Regression analysis; Research Note; Risk factors; Statistical analysis; Stem cell transplantation; Transplantation, Autologous; Treatment Outcome; UCP-2; Uncoupling Protein 2 - genetics
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-021-05758-7

Studies on the genetic background of patients with multiple myeloma (MM) have been increasing; two important factors considered in such works are uncoupling protein-2 (UCP-2) and nuclear receptor subfamily 3 group C member 1 (NR3C1). We aim to reveal the association of MM with NR3C1 and UCP-2 gene polymorphisms. In this prospective study, 200 patients diagnosed between January 2009 and 2018 and 200 healthy individuals were included. For patients who had undergone autologous stem cell transplantation and control subjects, we statistically compared the CC, GC, and GG genotypes and the C and G alleles of the NR3C1 gene, as well as the AA, AG, and GG genotypes and the A and G alleles of the UCP-2 gene. While the AA genotype was significantly more common in the MM group (p = 0.001), the GG genotype was significantly more common in the control group (p = 0.016). Overall survival was found to be significantly shorter in patients with the UCP-2 GG genotype (p = 0.034). It was also found that having the GG genotype of the UCP-2 gene was a 2.48-fold risk factor for mortality. The fact that overall survival is significantly shorter in MM patients with the UCP-2 GG genotype and its definition as a risk factor for mortality have been put forward for the first time in the literature.