Estimating incidence rates of grouped HPV types: A systematic review and comparison of the impact of different epidemiological assumptions

Some studies on human papillomavirus (HPV) provide not only type-specific incidence rates (IR), but also IRs of HPV groupings (e.g. the nonavalent grouping). We made an inventory of the different approaches used to calculate such IRs and assessed their impact on the estimated IRs of HPV groupings. W...

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Bibliographic Details
Published in:Papillomavirus research 2019-12, Vol.8, p.100187-100187, Article 100187
Main Authors: Jongen, Vita W., van Santen, Daniëla K., Alberts, Catharina J., Schim van der Loeff, Maarten F.
Format: Article
Language:English
Subjects:
Epidemiology
Female
Genotype
Homosexuality, Male
HPV
Human papillomavirus
Humans
Incidence
Incidence rate
Male
Papillomaviridae - classification
Papillomaviridae - genetics
Papillomavirus Infections - epidemiology
Papillomavirus Infections - transmission
Papillomavirus Infections - virology
Public Health Surveillance
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Summary:Some studies on human papillomavirus (HPV) provide not only type-specific incidence rates (IR), but also IRs of HPV groupings (e.g. the nonavalent grouping). We made an inventory of the different approaches used to calculate such IRs and assessed their impact on the estimated IRs of HPV groupings. We performed a systematic review assessing all approaches used in literature to estimate IRs. Subsequently we applied these approaches to data of a Dutch cohort study on HPV in men who have sex with men (H2M). IRs were estimated for six different HPV groupings. The systematic review yielded six different approaches (A-F) for estimating the IRs, varying in exclusion criteria at baseline, and the definitions of an incident event and person-time. Applying these approaches to the H2M dataset (n = 749), we found differences in the number of participants at risk, number of incidents events, person-time, and IR. For example, for the nonavalent grouping, depending on the approach chosen, the IR varied between 3.09 and 6.54 per 100 person-months. In published studies different epidemiological assumptions are used to estimate IRs of grouped HPV types, leading to widely differing estimates of IRs. IRs between different studies may therefore not be comparable.
ISSN:2405-8521
2405-8521
DOI:10.1016/j.pvr.2019.100187