Studies on the synthesis and reactivity of novel benzofuran-2-yl-[3-methyl-3-phenylcyclobutyl] methanones and their antimicrobial activity

Preparation in excellent yields of cyclobutyl benzofuran-2-yl- and naphthofuran- 2-yl-ketones, the corresponding ketoximes and thiosemicarbazones, ether derivatives of the ketoximes and thiazoles derived from the thiosemicarbazones are described. Two of the synthesized compounds have been tested aga...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2005-08, Vol.10 (7), p.747-754
Main Authors: Koca, Murat, Ahmedzade, Misir, Cukurovali, Alaaddin, Kazaz, Cavit
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - chemistry
Antimicrobial agents
Benzofurans - chemistry
Chemistry
cyclobutane
Cyclobutanes - chemistry
Cyclobutanes - pharmacology
DNA Damage
Furans
Lignans - chemistry
Lignans - pharmacology
Models, Molecular
Molecular Structure
oxime
Oximes - chemistry
Oximes - pharmacology
Potassium
Structure-Activity Relationship
thiazole
Thiazoles - chemistry
Thiazoles - pharmacology
thiosemicarbazone
Thiosemicarbazones - chemistry
Thiosemicarbazones - pharmacology
Ultraviolet Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preparation in excellent yields of cyclobutyl benzofuran-2-yl- and naphthofuran- 2-yl-ketones, the corresponding ketoximes and thiosemicarbazones, ether derivatives of the ketoximes and thiazoles derived from the thiosemicarbazones are described. Two of the synthesized compounds have been tested against eight different microorganisms and found to be active against some of the species studied.
ISSN:1420-3049
1420-3049
DOI:10.3390/10070747