Predominant secondary dengue infection among Vietnamese adults mostly without warning signs and severe disease

•Secondary infections prevail in North Vietnamese adults with few cases of severe disease.•Dengue virus serotypes DENV1 and DENV2 are predominant with higher viremia in primary infection than secondary infection.•Adult secondary dengue infection is distinguished by IgM:IgG ratio cut off

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Bibliographic Details
Published in:International journal of infectious diseases 2020-11, Vol.100, p.316-323
Main Authors: Lytton, Simon D., Nematollahi, Ghazaleh, van Tong, Hoang, Xuan Anh, Chu, Hung, Hoang Vu, Hoan, Nghiem Xuan, Diez, Gerold, Schumacher, Thomas, Landt, Offert, Melchior, Walter, Fuchs, Dietmar, Toan, Nguyen Linh, Velavan, Thirumalaisamy P., Song, Le Huu
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral - blood
Coinfection - blood
Coinfection - diagnosis
Coinfection - epidemiology
Coinfection - virology
Dengue
Dengue - blood
Dengue - diagnosis
Dengue - epidemiology
Dengue - virology
Dengue Virus - classification
Dengue Virus - genetics
Dengue Virus - isolation & purification
Dengue Virus - physiology
DENV serotypes
Enzyme-Linked Immunosorbent Assay - methods
Female
Hospital stay
Humans
IgM:IgG ratio
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M - blood
Male
Middle Aged
Primary infection
RNA, Viral - genetics
Secondary infection
Serogroup
Thrombocytopenia
Vietnam - epidemiology
Young Adult
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Description
Summary:•Secondary infections prevail in North Vietnamese adults with few cases of severe disease.•Dengue virus serotypes DENV1 and DENV2 are predominant with higher viremia in primary infection than secondary infection.•Adult secondary dengue infection is distinguished by IgM:IgG ratio cut off
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2020.08.082