Effects of Boron-Containing Compounds on Liposoluble Hormone Functions

Boron-containing compounds (BCC), particularly boronic acids and derivatives, are being increasingly tested as diagnostic and therapeutic agents. Some effects of BCC involve phenomena linked to the action of steroid or thyroid hormones; among these, are the effects on muscle mass or basal metabolism...

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Bibliographic Details
Published in:Inorganics 2023-02, Vol.11 (2), p.84
Main Authors: Estevez-Fregoso, Elizabeth, Kilic, Ahmet, Rodríguez-Vera, Diana, Nicanor-Juárez, Luis E, Romero-Rizo, C. Elena M, Farfán-García, Eunice D, Soriano-Ursúa, Marvin A
Format: Article
Language:English
Subjects:
Adducts
Analysis
Androgens
Binding sites
Boron
Breast cancer
Chemical compounds
Contraceptives
Damage
Diols
DNA damage
Drug metabolism
Energy sources
Estrogens
Experiments
Fertility
Fluorides
Globulins
Hormones
Infertility
Ligands
Mammals
medicinal chemistry
Metabolism
Muscles
Pharmacodynamics
Pharmacokinetics
Pharmacology
Plasma
Sex hormones
SHGB
Steroid hormones
Steroids
Testosterone
Thyroid gland
Thyroid hormones
Toxicity
Toxicology
vitamin D
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Summary:Boron-containing compounds (BCC), particularly boronic acids and derivatives, are being increasingly tested as diagnostic and therapeutic agents. Some effects of BCC involve phenomena linked to the action of steroid or thyroid hormones; among these, are the effects on muscle mass or basal metabolism. Additionally, some toxicology reports on mammals, including humans, sound an alert concerning damage to several systems, among which are the negative effects on the induction of male infertility. Systemic and local mechanisms to explain changes in metabolism and impaired fertility were collected and presented. Then, we presented the putative pharmacodynamic and pharmacokinetic mechanisms involved and demonstrated in these events. In addition, it is proposed that there are adducts of some oxygenated BCC with cis-diols in fructose, an essential source of energy for sperm–cell motility, an uncoupling of sex hormone-binding globulin (SHBG) and its ligands, and the modulation of the DNA synthetic rate. These effects share the reactivity of boron-containing compounds on the cis-diols of key molecules. Moreover, data reporting no DNA damage after BCC administration are included. Further studies are required to support the clear role of BCC through these events to disrupt metabolism or fertility in mammals. If such phenomena are confirmed and elucidated, an advance could be useful to design strategies for avoiding BCC toxicity after BCC administration, and possibly for designing metabolism regulators and contraceptive drugs, among other purposes. Boronic derivatives and carboranes have been proposed and studied in this field.
ISSN:2304-6740
2304-6740
DOI:10.3390/inorganics11020084