Roles of Two-Component Signal Transduction Systems in Shigella Virulence

Two-component signal transduction systems (TCSs) are widespread types of protein machinery, typically consisting of a histidine kinase membrane sensor and a cytoplasmic transcriptional regulator that can sense and respond to environmental signals. TCSs are responsible for modulating genes involved i...

Full description

Saved in:
Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-09, Vol.12 (9), p.1321
Main Authors: Pasqua, Martina, Coluccia, Marco, Eguchi, Yoko, Okajima, Toshihide, Grossi, Milena, Prosseda, Gianni, Utsumi, Ryutaro, Colonna, Bianca
Format: Article
Language:English
Subjects:
Adaptation
Antibiotic resistance
Bacteria
Bacterial infections
bacterial regulation
Binding sites
Biofilms
Care and treatment
Cell differentiation
Cell division
Cellular signal transduction
Chromosomes
Drug resistance
Environmental effects
EnvZ protein
Gene expression
Genetic aspects
Genomes
Histidine
Histidine kinase
Kinases
Motility
Pathogenicity
Pathogens
Phenotypes
Physiological aspects
Proteins
Review
RNA polymerase
Shigella
Shigella virulence
Signal transduction
stress response
two-component signal transduction systems
Virulence
Virulence (Microbiology)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two-component signal transduction systems (TCSs) are widespread types of protein machinery, typically consisting of a histidine kinase membrane sensor and a cytoplasmic transcriptional regulator that can sense and respond to environmental signals. TCSs are responsible for modulating genes involved in a multitude of bacterial functions, including cell division, motility, differentiation, biofilm formation, antibiotic resistance, and virulence. Pathogenic bacteria exploit the capabilities of TCSs to reprogram gene expression according to the different niches they encounter during host infection. This review focuses on the role of TCSs in regulating the virulence phenotype of Shigella, an intracellular pathogen responsible for severe human enteric syndrome. The pathogenicity of Shigella is the result of the complex action of a wide number of virulence determinants located on the chromosome and on a large virulence plasmid. In particular, we will discuss how five TCSs, EnvZ/OmpR, CpxA/CpxR, ArcB/ArcA, PhoQ/PhoP, and EvgS/EvgA, contribute to linking environmental stimuli to the expression of genes related to virulence and fitness within the host. Considering the relevance of TCSs in the expression of virulence in pathogenic bacteria, the identification of drugs that inhibit TCS function may represent a promising approach to combat bacterial infections.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12091321