Safety and Efficacy of Tranexamic Acid in Spinal Surgery: A Systematic Review and Meta-Analysis

Background: Tranexamic acid (TXA) has gained popularity in spinal surgery because of its potential to reduce blood loss. However, concerns regarding its safety and efficacy remain.This systematic review and meta-analysis aimed to evaluate the efficacy of TXA in reducing blood loss and its safety pro...

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Bibliographic Details
Published in:Spine Surgery and Related Research 2024/05/27, Vol.8(3), pp.253-266
Main Authors: Yamanouchi, Kento, Funao, Haruki, Fujita, Naruhito, Ebata, Shigeto, Yagi, Mitsuru
Format: Article
Language:English
Subjects:
Blood Loss
Complications
Meta-Analysis
Review
Spinal Surgery
Systematic Review
Tranexamic Acid
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Summary:Background: Tranexamic acid (TXA) has gained popularity in spinal surgery because of its potential to reduce blood loss. However, concerns regarding its safety and efficacy remain.This systematic review and meta-analysis aimed to evaluate the efficacy of TXA in reducing blood loss and its safety profile in spinal surgeries.Methods: A comprehensive search was conducted in electronic databases for randomized controlled trials and prospective studies evaluating the use of TXA in spinal surgery. The primary outcomes were intraoperative and total estimated blood loss (EBL), and the secondary outcomes included the incidence and types of complications associated with TXA use. Meta-analyses were performed using random-effects models.Results: Thirteen studies involving 1,213 participants were included in the meta-analysis. The use of TXA was associated with significant reductions in both intraoperative (mean difference: −46.56 mL [−73.85, −19.26], p
ISSN:2432-261X
2432-261X
DOI:10.22603/ssrr.2023-0244