ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients

Innate lymphoid cells (ILCs) are emerging as important players in inflammatory diseases. The oral mucosal barrier harbors all ILC subsets, but how these cells regulate the immune responses in periodontal ligament tissue during periodontitis remains undefined. Here, we show that total ILCs are marked...

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Bibliographic Details
Published in:Frontiers in immunology 2021-07, Vol.12, p.708678-708678
Main Authors: Li, Changyi, Liu, Jianyue, Pan, Jie, Wang, Yuhui, Shen, Lei, Xu, Yan
Format: Article
Language:English
Subjects:
Adult
Female
Humans
IFN-γ
IL-17A
Immunity, Innate
Immunology
inflammation
innate lymphoid cells
Interferon-gamma - biosynthesis
Interleukin-17 - biosynthesis
Lymphocytes - immunology
Male
Middle Aged
Natural Cytotoxicity Triggering Receptor 2 - analysis
periodontal ligament
Periodontal Ligament - immunology
periodontitis
Periodontitis - immunology
Phenotype
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Summary:Innate lymphoid cells (ILCs) are emerging as important players in inflammatory diseases. The oral mucosal barrier harbors all ILC subsets, but how these cells regulate the immune responses in periodontal ligament tissue during periodontitis remains undefined. Here, we show that total ILCs are markedly increased in periodontal ligament of periodontitis patients compared with healthy controls. Among them, ILC1s and ILC3s, particularly NKp44 ILC3 subset, are the predominant subsets accumulated in the periodontal ligament. Remarkably, ILC1s and ILC3s from periodontitis patients produce more IL-17A and IFN-γ than that from healthy controls. Collectively, our results highlight the role of ILCs in regulating oral immunity and periodontal ligament inflammation and provide insights into targeting ILCs for the treatment of periodontitis.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.708678