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ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients
Innate lymphoid cells (ILCs) are emerging as important players in inflammatory diseases. The oral mucosal barrier harbors all ILC subsets, but how these cells regulate the immune responses in periodontal ligament tissue during periodontitis remains undefined. Here, we show that total ILCs are marked...
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| Published in: | Frontiers in immunology 2021-07, Vol.12, p.708678-708678 |
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| Main Authors: | , , , , , |
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| container_title | Frontiers in immunology |
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| creator | Li, Changyi Liu, Jianyue Pan, Jie Wang, Yuhui Shen, Lei Xu, Yan |
| description | Innate lymphoid cells (ILCs) are emerging as important players in inflammatory diseases. The oral mucosal barrier harbors all ILC subsets, but how these cells regulate the immune responses in periodontal ligament tissue during periodontitis remains undefined. Here, we show that total ILCs are markedly increased in periodontal ligament of periodontitis patients compared with healthy controls. Among them, ILC1s and ILC3s, particularly NKp44
ILC3 subset, are the predominant subsets accumulated in the periodontal ligament. Remarkably, ILC1s and ILC3s from periodontitis patients produce more IL-17A and IFN-γ than that from healthy controls. Collectively, our results highlight the role of ILCs in regulating oral immunity and periodontal ligament inflammation and provide insights into targeting ILCs for the treatment of periodontitis. |
| doi_str_mv | 10.3389/fimmu.2021.708678 |
| format | article |
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ILC3 subset, are the predominant subsets accumulated in the periodontal ligament. Remarkably, ILC1s and ILC3s from periodontitis patients produce more IL-17A and IFN-γ than that from healthy controls. Collectively, our results highlight the role of ILCs in regulating oral immunity and periodontal ligament inflammation and provide insights into targeting ILCs for the treatment of periodontitis.</description><identifier>ISSN: 1664-3224</identifier><identifier>EISSN: 1664-3224</identifier><identifier>DOI: 10.3389/fimmu.2021.708678</identifier><identifier>PMID: 34381457</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Adult ; Female ; Humans ; IFN-γ ; IL-17A ; Immunity, Innate ; Immunology ; inflammation ; innate lymphoid cells ; Interferon-gamma - biosynthesis ; Interleukin-17 - biosynthesis ; Lymphocytes - immunology ; Male ; Middle Aged ; Natural Cytotoxicity Triggering Receptor 2 - analysis ; periodontal ligament ; Periodontal Ligament - immunology ; periodontitis ; Periodontitis - immunology ; Phenotype</subject><ispartof>Frontiers in immunology, 2021-07, Vol.12, p.708678-708678</ispartof><rights>Copyright © 2021 Li, Liu, Pan, Wang, Shen and Xu.</rights><rights>Copyright © 2021 Li, Liu, Pan, Wang, Shen and Xu 2021 Li, Liu, Pan, Wang, Shen and Xu</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-aa08c42cf96b5a287bbbcd20cf517203da5f7bdfd9526144d4c62299c8f198f3</citedby><cites>FETCH-LOGICAL-c465t-aa08c42cf96b5a287bbbcd20cf517203da5f7bdfd9526144d4c62299c8f198f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350136/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350136/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34381457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Changyi</creatorcontrib><creatorcontrib>Liu, Jianyue</creatorcontrib><creatorcontrib>Pan, Jie</creatorcontrib><creatorcontrib>Wang, Yuhui</creatorcontrib><creatorcontrib>Shen, Lei</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><title>ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients</title><title>Frontiers in immunology</title><addtitle>Front Immunol</addtitle><description>Innate lymphoid cells (ILCs) are emerging as important players in inflammatory diseases. The oral mucosal barrier harbors all ILC subsets, but how these cells regulate the immune responses in periodontal ligament tissue during periodontitis remains undefined. Here, we show that total ILCs are markedly increased in periodontal ligament of periodontitis patients compared with healthy controls. Among them, ILC1s and ILC3s, particularly NKp44
ILC3 subset, are the predominant subsets accumulated in the periodontal ligament. Remarkably, ILC1s and ILC3s from periodontitis patients produce more IL-17A and IFN-γ than that from healthy controls. Collectively, our results highlight the role of ILCs in regulating oral immunity and periodontal ligament inflammation and provide insights into targeting ILCs for the treatment of periodontitis.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>IFN-γ</subject><subject>IL-17A</subject><subject>Immunity, Innate</subject><subject>Immunology</subject><subject>inflammation</subject><subject>innate lymphoid cells</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin-17 - biosynthesis</subject><subject>Lymphocytes - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natural Cytotoxicity Triggering Receptor 2 - analysis</subject><subject>periodontal ligament</subject><subject>Periodontal Ligament - immunology</subject><subject>periodontitis</subject><subject>Periodontitis - immunology</subject><subject>Phenotype</subject><issn>1664-3224</issn><issn>1664-3224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkctuEzEUQEcIRKvSD2CDvGST4Lc9GyQUFYgUiSy6N3f8SFzNjIPtIPL3uE0prTe-uo9jX52ue0_wkjHdfwpxmo5LiilZKqyl0q-6SyIlXzBK-etn8UV3Xcodbof3jDHxtrtgnGnChbrsfq43K1IQzA61iBV082cfh1jReg4jTBPUlE9ou_dzqqeDR3FGW59jcmmuMKJN3MHk54pS-J-PNRa0hRpbobzr3gQYi79-vK-62683t6vvi82Pb-vVl83CcinqAgBry6kNvRwEUK2GYbCOYhsEURQzByKowQXXCyoJ545bSWnfWx1IrwO76tZnrEtwZw45TpBPJkE0D4mUdwZyjXb0hg2KKSGdd0pwRRTAwEXAXoC1HgtorM9n1uE4TN7ZtkaG8QX0ZWWOe7NLv41mAhMmG-DjIyCnX0dfqplisX4cYfbpWAwVEmvW1iKtlZxbbU6lZB-eniHY3Hs2D57NvWdz9txmPjz_39PEP6vsL4K_pks</recordid><startdate>20210726</startdate><enddate>20210726</enddate><creator>Li, Changyi</creator><creator>Liu, Jianyue</creator><creator>Pan, Jie</creator><creator>Wang, Yuhui</creator><creator>Shen, Lei</creator><creator>Xu, Yan</creator><general>Frontiers Media S.A</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210726</creationdate><title>ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients</title><author>Li, Changyi ; Liu, Jianyue ; Pan, Jie ; Wang, Yuhui ; Shen, Lei ; Xu, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-aa08c42cf96b5a287bbbcd20cf517203da5f7bdfd9526144d4c62299c8f198f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>IFN-γ</topic><topic>IL-17A</topic><topic>Immunity, Innate</topic><topic>Immunology</topic><topic>inflammation</topic><topic>innate lymphoid cells</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin-17 - biosynthesis</topic><topic>Lymphocytes - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natural Cytotoxicity Triggering Receptor 2 - analysis</topic><topic>periodontal ligament</topic><topic>Periodontal Ligament - immunology</topic><topic>periodontitis</topic><topic>Periodontitis - immunology</topic><topic>Phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Changyi</creatorcontrib><creatorcontrib>Liu, Jianyue</creatorcontrib><creatorcontrib>Pan, Jie</creatorcontrib><creatorcontrib>Wang, Yuhui</creatorcontrib><creatorcontrib>Shen, Lei</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Frontiers in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Changyi</au><au>Liu, Jianyue</au><au>Pan, Jie</au><au>Wang, Yuhui</au><au>Shen, Lei</au><au>Xu, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients</atitle><jtitle>Frontiers in immunology</jtitle><addtitle>Front Immunol</addtitle><date>2021-07-26</date><risdate>2021</risdate><volume>12</volume><spage>708678</spage><epage>708678</epage><pages>708678-708678</pages><issn>1664-3224</issn><eissn>1664-3224</eissn><abstract>Innate lymphoid cells (ILCs) are emerging as important players in inflammatory diseases. The oral mucosal barrier harbors all ILC subsets, but how these cells regulate the immune responses in periodontal ligament tissue during periodontitis remains undefined. Here, we show that total ILCs are markedly increased in periodontal ligament of periodontitis patients compared with healthy controls. Among them, ILC1s and ILC3s, particularly NKp44
ILC3 subset, are the predominant subsets accumulated in the periodontal ligament. Remarkably, ILC1s and ILC3s from periodontitis patients produce more IL-17A and IFN-γ than that from healthy controls. Collectively, our results highlight the role of ILCs in regulating oral immunity and periodontal ligament inflammation and provide insights into targeting ILCs for the treatment of periodontitis.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>34381457</pmid><doi>10.3389/fimmu.2021.708678</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Female Humans IFN-γ IL-17A Immunity, Innate Immunology inflammation innate lymphoid cells Interferon-gamma - biosynthesis Interleukin-17 - biosynthesis Lymphocytes - immunology Male Middle Aged Natural Cytotoxicity Triggering Receptor 2 - analysis periodontal ligament Periodontal Ligament - immunology periodontitis Periodontitis - immunology Phenotype |
| title | ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients |
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