Loss of lower extremity muscle strength based on diabetic polyneuropathy in older patients with type 2 diabetes: Multicenter Survey of the Isometric Lower Extremity Strength in Type 2 Diabetes: Phase 2 study

• Published in: Journal of diabetes investigation 2021-03, Vol.12 (3), p.390-397
• Main Authors: Nomura, Takuo, Kawae, Toshihiro, Kataoka, Hiroaki, Ikeda, Yukio
• Format: Article
• Language: English
• Subjects: Activities of daily living; Age; Aged; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Neuropathies - complications; Diabetic Neuropathies - physiopathology; Diabetic neuropathy; Diabetic retinopathy; Disease; Drug therapy; Female; Glucose; Hospitals; Humans; Longitudinal Studies; Lower Extremity - physiopathology; Male; Mobility; Muscle contraction; Muscle Strength; Musculoskeletal system; Older patients; Original; Patients; Polyneuropathy; Quality of life
• ISSN: 2040-1116; 2040-1124
• DOI: 10.1111/jdi.13354

Aims/Introduction Diabetic polyneuropathy (DPN) is a factor that reduces lower extremity muscle strength (LEMS) in older type 2 diabetes patients. This relationship remains unclear in longitudinal studies. Therefore, we longitudinally investigated the apparent effects of DPN on changes in LEMS. Furthermore, we cross‐sectionally examined relationships among DPN, LEMS, mobility and health‐related quality of life. Materials and Methods Bodyweight‐normalized (relative) knee extension force (KEF) was examined in 51 DPN and 54 non‐DPN patients (68.9 ± 5.6 and 70.2 ± 5.9 years, respectively) at baseline and follow up at 3.6 ± 0.6 years. At follow up, mobility was measured using a 25‐question geriatric locomotive function scale. Health‐related quality of life was assessed using the five‐dimensions of EuroQol for quality‐adjusted life years calculation. Results Relative KEF in the DPN group was significantly lower at follow up (1.22 ± 0.47 Nm/kg) than at baseline (1.31 ± 0.47 Nm/kg; P