The biological function and clinical utilization of CD147 in human diseases: a review of the current scientific literature

CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokines. CD147 regulates cell proliferation, apoptosis,...

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Bibliographic Details
Published in:International journal of molecular sciences 2014-09, Vol.15 (10), p.17411-17441
Main Authors: Xiong, Lijuan, Edwards, 3rd, Carl K, Zhou, Lijun
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - therapeutic use
Basigin - immunology
Basigin - metabolism
biological function
Biomarkers, Tumor - metabolism
Cancer
CD147
diagnostic biomarkers
Disease Models, Animal
EMMPRIN
Humans
Immunoglobulins
matrix metalloproteinases (MMPs)
Matrix Metalloproteinases - metabolism
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - metabolism
Pathogenesis
Protein expression
Review
therapeutic target
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Summary:CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokines. CD147 regulates cell proliferation, apoptosis, and tumor cell migration, metastasis and differentiation, especially under hypoxic conditions. CD147 is also important to many organ systems. This review will provide a detailed overview of the discovery, characterization, molecular structure, diverse biological functions and regulatory mechanisms of CD147 in human physiological and pathological processes. In particular, recent studies have demonstrated the potential application of CD147 not only as a phenotypic marker of activated regulatory T cells but also as a potential diagnostic marker for early-stage disease. Moreover, CD147 is recognized as an effective therapeutic target for hepatocellular carcinoma (HCC) and other cancers, and exciting clinical progress has been made in HCC treatment using CD147-directed monoclonal antibodies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms151017411