Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial

Chronic kidney disease with metabolic acidosis is common in older people, but the effectiveness of oral sodium bicarbonate therapy in this group is unclear. We tested whether oral sodium bicarbonate provides net health benefit for older people with advanced chronic kidney disease and serum bicarbona...

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Published in:BMC medicine 2020-04, Vol.18 (1), p.91-91, Article 91
Main Authors: Duncan, Neill, Sumukadas, Deepa, Avenell, Alison, Rauchhaus, Petra, Mishra, Biswa, Stevens, Paul E, Warwick, Graham, Balasubramaniam, Gowrie, Hampson, Geeta, Band, Margaret, Lambie, Stewart, Witham, Miles D, Chong, Huey Yi, Wilkie, Martin, Tse, Wai, Ahmed, Aimun, McNamee, Paul, Lamb, Edmund J, Plews, Deirdre, Kirk, Adam, Bhatnagar, Deepak, Winnett, Georgia, Kennedy, Gwen, Mitra, Sandip, Donnan, Peter T, Kalra, Philip A, Soiza, Roy L, Chan, Anthony, Littleford, Roberta, Basnayake, Kolitha, Hu, May Khei, Nicholas, Johann, Almond, Michael K
Format: Article
Language:English
Subjects:
Acidosis
Acidosis - drug therapy
Age
Aged
Anthropometry
Batteries
Bicarbonates - blood
Biomarkers - blood
Blood pressure
Bone density
Carbonates
Chronic kidney failure
Clinical medicine
Clinical trials
Cost-Benefit Analysis - methods
Dialysis
Double-Blind Method
Double-blind studies
Elderly patients
Female
Glomerular filtration rate
Health care costs
Health services
Humans
Hypertension
Kidney diseases
Kidneys
Male
Metabolic acidosis
Metabolism
Nephrology
Older people
Patients
Phosphatase
Quality of life
Quality of Life - psychology
Randomised controlled trial
Randomization
Renal function
Renal insufficiency, chronic
Renal Insufficiency, Chronic - drug therapy
Sensitivity analysis
Sodium
Sodium bicarbonate
Sodium Bicarbonate - administration & dosage
Sodium Bicarbonate - economics
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Summary:Chronic kidney disease with metabolic acidosis is common in older people, but the effectiveness of oral sodium bicarbonate therapy in this group is unclear. We tested whether oral sodium bicarbonate provides net health benefit for older people with advanced chronic kidney disease and serum bicarbonate concentrations
ISSN:1741-7015
1741-7015
DOI:10.1186/s12916-020-01542-9