Treatment of cutaneous lesion of 20 years' duration caused by leishmanization

The inoculation of live Leishmania (L.) major to produce a single lesion is called leishmanization (LZ). LZ lesion upon cure prevents further natural infection which might be multiple lesions on unwanted sites such as face. Cutaneous leishmaniasis (CL) usually leads to a self healing lesion; though...

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Bibliographic Details
Published in:Indian journal of dermatology 2012-03, Vol.57 (2), p.123-125
Main Authors: Khamesipour, Ali, Abbasi, Azam, Firooz, Alireza, Mohammadi, Akram Mir Amin, Eskandari, Seyed Ebrahim, Jaafari, Mahmoud R
Format: Article
Language:English
Subjects:
Aminoglycosides
Case studies
Dermatology
Diagnosis
Dosage and administration
Drug therapy
Immunization
L. major lesion
Leishmaniasis, Cutaneous
Leishmanization
Medical treatment
Methods
non-healing
Parasitic diseases
paromomycin
Skin
Skin lesions
Therapeutic Round
treatment of cutaneous leishmaniasis
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Summary:The inoculation of live Leishmania (L.) major to produce a single lesion is called leishmanization (LZ). LZ lesion upon cure prevents further natural infection which might be multiple lesions on unwanted sites such as face. Cutaneous leishmaniasis (CL) usually leads to a self healing lesion; though rarely the lesion persists and becomes refractory to all types of remedies. Here, we present a 41-year-old patient with a 20-year history of cutaneous lesion caused by leishmanization. The causative agent is identified as L. major. The patient did not respond to treatment with meglumine antimoniate, 20 mg/kg/day Sb(+5) for three weeks and allopurinol 10 mg/kg for four weeks. After two months, the same treatment was repeated. In addition, a topical liposomal preparation containing 10% paromomycin sulfate was administered twice a day for four weeks. The lesion showed marked improvement during the treatment and was eventually completely healed.
ISSN:0019-5154
1998-3611
DOI:10.4103/0019-5154.94280