The effect of blood lipids on the comorbidity of multiple large arachnoid granulations

Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research. The study included patients diagnosed with cerebral venous sinus sten...

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Bibliographic Details
Published in:Lipids in health and disease 2024-10, Vol.23 (1), p.351-9, Article 351
Main Authors: Guo, Yibing, Wang, Zhongao, Gao, Meini, Zhou, Da, Ding, Yuchuan, Ji, Xunming, Meng, Ran
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Analysis and chemistry
Arachnoid - diagnostic imaging
Arachnoid - pathology
Arachnoid granulation
Blood
Blood lipid
Blood lipids
Care and treatment
Cerebral venous sinus stenosis
Cholesterol - blood
Cholesterol, LDL - blood
Comorbidity
Complications and side effects
Diagnosis
Dyslipidemia
Dyslipidemias - blood
Dyslipidemias - epidemiology
Female
High-resolution black blood magnetic resonance imaging
Humans
Intracranial hypertension
Lipids - blood
Magnetic Resonance Imaging
Male
Middle Aged
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Summary:Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research. The study included patients diagnosed with cerebral venous sinus stenosis (CVSS) related to LAG. The number of LAGs was assessed via high-resolution black blood magnetic resonance imaging. The relationships between blood lipids and multiple LAGs were explored to evaluate the effects of dyslipidemia on the formation of multiple LAGs. A total of 163 participants with a diagnosis of LAG were included. The levels of total cholesterol (TC) (P = 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.01) in the multiple LAGs group were greater than those in the non-multiple LAGs group. Multivariate logistic regression analysis revealed that TC (odds ratio (OR), 2.19; 95% confidence interval (CI), 1.26-3.80; P = 0.006) and LDL-c (OR, 2.18; 95% CI, 1.16-4.07; P = 0.02) were independently associated with multiple LAGs. TC and LDL-c are independently related to multiple LAGs, indicating that dyslipidemia may be a potential cause of CVSS. Therefore, monitoring blood lipids may be necessary for patients with LAGs.
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-024-02341-4