Point Prevalence Survey of Antibiotic Use across 13 Hospitals in Uganda

Standardized monitoring of antibiotic use underpins the effective implementation of antimicrobial stewardship interventions in combatting antimicrobial resistance (AMR). To date, few studies have assessed antibiotic use in hospitals in Uganda to identify gaps that require intervention. This study ap...

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Bibliographic Details
Published in:Antibiotics (Basel) 2022-02, Vol.11 (2), p.199
Main Authors: Kiggundu, Reuben, Wittenauer, Rachel, Waswa, J P, Nakambale, Hilma N, Kitutu, Freddy Eric, Murungi, Marion, Okuna, Neville, Morries, Seru, Lawry, Lynn Lieberman, Joshi, Mohan P, Stergachis, Andy, Konduri, Niranjan
Format: Article
Language:English
Subjects:
antibiotic use surveillance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
antimicrobial stewardship
antimicrobials
Benchmarks
Catheters
Ceftriaxone
Cellulitis
Cloxacillin
Compliance
COVID-19
Data collection
Drug resistance
Guidelines
Health facilities
hospital
Hospital patients
Hospitals
Infections
Medical research
Medicine, Experimental
Metronidazole
Patients
Pneumonia
point prevalence survey
Polls & surveys
Prescriptions
Public health
Sepsis
Sulbactam
Surveillance
Surveys
Tanzania
Uganda
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Summary:Standardized monitoring of antibiotic use underpins the effective implementation of antimicrobial stewardship interventions in combatting antimicrobial resistance (AMR). To date, few studies have assessed antibiotic use in hospitals in Uganda to identify gaps that require intervention. This study applied the World Health Organization's standardized point prevalence survey methodology to assess antibiotic use in 13 public and private not-for-profit hospitals across the country. Data for 1077 patients and 1387 prescriptions were collected between December 2020 and April 2021 and analyzed to understand the characteristics of antibiotic use and the prevalence of the types of antibiotics to assess compliance with Uganda Clinical Guidelines; and classify antibiotics according to the WHO Access, Watch, and Reserve classification. This study found that 74% of patients were on one or more antibiotics. Compliance with Uganda Clinical Guidelines was low (30%); Watch-classified antibiotics were used to a high degree (44% of prescriptions), mainly driven by the wide use of ceftriaxone, which was the most frequently used antibiotic (37% of prescriptions). The results of this study identify key areas for the improvement of antimicrobial stewardship in Uganda and are important benchmarks for future evaluations.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11020199