Effects of pre-extraction intermittent PTH administration on extraction socket healing in bisphosphonate administered ovariectomized rats

The purpose of this study was to investigate the effect of administering intermittent parathyroid hormone (iPTH) before tooth extraction versus after tooth extraction on the risk of developing MRONJ in experimental animal model. Twenty-five ovariectomized rats received 6 weeks of bisphosphonate ther...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.54-54, Article 54
Main Authors: Kim, Jae-Young, Jang, Hyo-Won, Kim, Jung-In, Cha, In-Ho
Format: Article
Language:English
Subjects:
692/699/3017
692/699/3020
Animal models
Bisphosphonates
Bone healing
Bone histomorphometry
Computed tomography
Humanities and Social Sciences
multidisciplinary
Ovariectomy
Parathyroid
Parathyroid hormone
Science
Science (multidisciplinary)
Teeth
Tooth extractions
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Summary:The purpose of this study was to investigate the effect of administering intermittent parathyroid hormone (iPTH) before tooth extraction versus after tooth extraction on the risk of developing MRONJ in experimental animal model. Twenty-five ovariectomized rats received 6 weeks of bisphosphonate therapy. They were classified into 3 groups, based on the timing of the medication, as Control, Pre-PTH and Post-PTH groups. For Control group, normal saline was administered before and after tooth extraction. iPTH was administered during 4 weeks before tooth extraction for Pre-PTH group and after tooth extraction for Post-PTH group. The animals were euthanized 8 weeks after tooth extraction. Macroscopic, histological, micro-computed tomography (micro-CT), and histomorphometric examinations were conducted. The incidences of impaired healing were 11.11% both in Pre-PTH and Post-PTH groups, which was lower than the Control group (42.86%). Bone healing in the extraction socket, based on micro-CT and histomorphometry evaluations, was best in Post-PTH and worst in Control group. The Pre-PTH group showed moderate healing pattern. Despite of limitations in this study, the authors identified Pre-PTH group seems to have positive effect on extraction socket healing. With regard to timing, administering iPTH after tooth extraction was superior to applying it before tooth extraction.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-79787-w