Natural Killer T-like Cells: Immunobiology and Role in Disease

CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview...

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Published in:International journal of molecular sciences 2023-02, Vol.24 (3), p.2743
Main Authors: Almeida, Jani-Sofia, Casanova, José Manuel, Santos-Rosa, Manuel, Tarazona, Raquel, Solana, Rafael, Rodrigues-Santos, Paulo
Format: Article
Language:English
Subjects:
ageing
Aging
Aging (natural)
Antigens
Antigens, CD1d
CD1d antigen
CD56 antigen
Cell differentiation
Cytomegalovirus
Cytotoxicity
Genotype & phenotype
Humans
infection
Infections
inflammation
innate-like cells
Killer Cells, Natural
Lymphocytes
Lymphocytes T
Major histocompatibility complex
Medical innovations
Natural killer cells
Natural Killer T-Cells
natural killer T-like cells
pregnancy
Review
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Summary:CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differentiated T cells with "CD1d-independent" antigen recognition and MHC-unrestricted cell killing. The genesis of NKT-like cells is unclear; however, it is proposed that the acquisition of innate characteristics by T cells could represent a remodeling process leading to successful aging. Additionally, it has been shown that NKT-like cells may play a significant role in several pathological conditions, making it necessary to comprehend whether these cells might function as prognostic markers. The quantification and characterization of these cells might serve as a cutting-edge indicator of individual immune health. Additionally, exploring the mechanisms that can control their killing activity in different contexts may therefore result in innovative therapeutic alternatives in a wide range of disease settings.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24032743