Bridging the gap between toxicity and carcinogenicity of mineral fibres by connecting the fibre crystal-chemical and physical parameters to the key characteristics of cancer

• Published in: Current research in toxicology 2021-01, Vol.2, p.42-52
• Main Author: Gualtieri, Alessandro F.
• Format: Article
• Language: English
• Subjects: Asbestos; FPTI; IARC, mesothelioma, cancer; In vitro toxicity; Pathogenicity
• ISSN: 2666-027X; 2666-027X
• DOI: 10.1016/j.crtox.2021.01.005

[Display omitted] •The model attempts to bridge toxicity and carcinogenicity of mineral fibres.•The model measures the toxicity and pathogenic potential of asbestos minerals.•The model predicts the toxicity and pathogenicity of unregulated/unclassified fibres.•The model reveals the fibre parameters active as key characteristics of cancer. Airborne fibres and particularly asbestos represent hazards of great concern for human health because exposure to these peculiar particulates may cause malignancies such as lung cancer and mesothelioma. Currently, many researchers worldwide are focussed on fully understanding the patho-biological mechanisms leading to carcinogenesis prompted by pathogenic fibres. Along this line, the present work introduces a novel approach to correlate how and to what extent the physical/crystal-chemical and morphological parameters (including length, chemistry, biodurability, and surface properties) of mineral fibres cause major adverse effects with an emphasis on asbestos. The model described below conceptually attempts to bridge the gap between toxicity and carcinogenicity of mineral fibres and has several implications: 1) it provides a tool to measure the toxicity and pathogenic potential of asbestos minerals, allowing a quantitative rank of the different types (e.g. chrysotile vs. crocidolite); 2) it can predict the toxicity and pathogenicity of “unregulated” or unclassified fibres; 3) it reveals the parameters of a mineral fibre that are active in stimulating key characteristics of cancer, thus offering a strategy for developing specific cancer prevention strategies and therapies. Chrysotile, crocidolite and fibrous glaucophane are described here as mineral fibres of interest.