Distribution of Class D Carbapenemase and Extended-Spectrum β-Lactamase Genes among Acinetobacter Baumannii Isolated from Burn Wound and Ventilator Associated Pneumonia Infections

Resistance to is dramatically on the rise in Iran. Therefore, it is important to study resistance pattern among isolates which is a common cause of nosocomial infections. To investigate antibiotic resistance patterns and the role of resistant genes and biofilm formation in the induction of resistanc...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2017-07, Vol.11 (7), p.DC19-DC23
Main Authors: Mohammadi, Maryam, Soroush, Setareh, Delfani, Somayeh, Pakzad, Iraj, Abbaszadeh, Abolfazl, Bahmani, Mahmoud, Bogdanovic, Lidija, Taherikalani, Morovat
Format: Article
Language:English
Subjects:
insertion elements
nosocomial infections
β-lactams
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Summary:Resistance to is dramatically on the rise in Iran. Therefore, it is important to study resistance pattern among isolates which is a common cause of nosocomial infections. To investigate antibiotic resistance patterns and the role of resistant genes and biofilm formation in the induction of resistance among isolated from burn wound and ventilator associated pneumonia infections. Total 103 isolates such as 33 burn samples from Rasool Akram Hospital and 70 isolates from ventilated patients in Shahid Motahhari Hospital were identified with . using biochemical method, and then identified to species level with PCR of and gene. Antibiotic sensitivity pattern for β-lactam and carbapenem antibiotics was assessed using Agar disc diffusion test and E-test. The presence of different carbapenemase and metalo-β-lactamase ( , , , , , , , , , , ), extended-spectrum β-lactamases ( , ) and two insertion sequences genes ( , ) was assessed. Biofilm formation of all isolates was then assessed. Chi-square analysis or Fisher's-exact tests were used for statistical analysis. A p-value
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2017/25534.10218