Revisiting Genetic Influence on Mercury Exposure and Intoxication in Humans: A Scoping Review

Human intoxication to mercury is a worldwide health problem. In addition to the type and length of exposure, the genetic background plays an important role in mercury poisoning. However, reviews on the genetic influence in mercury toxicity are scarce and not systematic. Therefore, this review aimed...

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Bibliographic Details
Published in:Toxics (Basel) 2023-11, Vol.11 (12), p.967
Main Authors: Crespo-Lopez, Maria Elena, Barthelemy, Jean Ludger, Lopes-Araújo, Amanda, Santos-Sacramento, Leticia, Leal-Nazaré, Caio Gustavo, Soares-Silva, Isabela, Macchi, Barbarella M, do Nascimento, José Luiz M, Arrifano, Gabriela de Paula, Augusto-Oliveira, Marcus
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Amazon
Apolipoprotein E
ATP-binding protein
Biomarkers
Brain-derived neurotrophic factor
Causes of
Drunkenness (Criminal law)
Evaluation
Exposure
Food contamination & poisoning
Genes
Glutathione
Hair
health
Health aspects
Intoxication
Mercury
Mercury (metal)
Metallothionein
methylmercury
Nucleotides
Poisoning
polymorphism
Public health administration
Review
Reviews
River basins
Single-nucleotide polymorphism
SNP
susceptibility
Toxicity
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Summary:Human intoxication to mercury is a worldwide health problem. In addition to the type and length of exposure, the genetic background plays an important role in mercury poisoning. However, reviews on the genetic influence in mercury toxicity are scarce and not systematic. Therefore, this review aimed to systematically overview the most recent evidence on the genetic influence (using single nucleotide polymorphisms, SNPs) on human mercury poisoning. Three different databases (PubMed/Medline, Web of Science and Scopus) were searched, and 380 studies were found that were published from 2015 to 2022. After applying inclusion/exclusion criteria, 29 studies were selected and data on characteristics (year, country, profile of participants) and results (mercury biomarkers and quantitation, SNPs, main findings) were extracted and analyzed. The largest number of studies was performed in Brazil, mainly involving traditional populations of the Tapajós River basin. Most studies evaluated the influence of the SNPs related to genes of the glutathione system (GST, GPx, etc.), the ATP-binding cassette transporters and the metallothionein proteins. The recent findings regarding other SNPs, such as those of apolipoprotein E and brain-derived neurotrophic factor genes, are also highlighted. The importance of the exposure level is discussed considering the possible biphasic behavior of the genetic modulation phenomena that could explain some SNP associations. Overall, recommendations are provided for future studies based on the analysis obtained in this scoping review.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics11120967