KL-6 in adult polymyositis and dermatomyositis patients and its correlation with interstitial lung disease

Background Pulmonary involvement is still regarded as a common cause of morbidity in Polymyositis/Dermatomyositis. Interstitial lung disease can result in potentially fatal consequences such as ventilatory failure, secondary pulmonary arterial hypertension, or cor pulmonale. Early diagnosis of inter...

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Published in:Egyptian Rheumatology and Rehabilitation 2023-12, Vol.50 (1), p.64-10, Article 64
Main Authors: Khalil, Mayada, Fouda, Ali Ibrahim, Amin, Nashwa Ahmed, Ali, Ahmed Saied Mohammed, Shams, Ghada Mohammed, Sheiha, Soheir Hussein
Format: Article
Language:English
Subjects:
Age
Biopsy
Chronic illnesses
Creatinine
Dermatomyositis
Disease
Enzymes
Females
Hospitals
HRCT
ILD
Kinases
KL-6
Laboratories
Males
Medicine
Medicine & Public Health
Monoclonal antibodies
PFT
Pneumonia
Polymyositis
Rehabilitation
Skin
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Summary:Background Pulmonary involvement is still regarded as a common cause of morbidity in Polymyositis/Dermatomyositis. Interstitial lung disease can result in potentially fatal consequences such as ventilatory failure, secondary pulmonary arterial hypertension, or cor pulmonale. Early diagnosis of interstitial lung disease is hence a top priority in Polymyositis/Dermatomyositis patients. Krebs von den Lungen-6 is a transmembrane mucoprotein that has recently been identified as a promising marker for interstitial lung disease diagnosis and progression. As a result, it is regarded as a powerful predictor of interstitial lung disease severity. Thirty polymyositis/dermatomyocitis patients were enrolled in this study. Thirty age and sex matched healthy individuals were selected as control group. Cutaneous Dermatomyositis Disease Area Severity index(CDASI) was used for evaluation of skin severity, KL6 was measured using Elisa kit, High-resolution computed tomography, pulmonary function tests were made. Results Sixteen female and 14 male patients had a mean age of 41.64–8.02 and amedian of the disease duration of 4 years. Fifteen patients (50%) had normal readings on High-resolution computed tomography of the chest HRCT chest, while the other half had significant HRCT chest findings. KL-6 concentrations were seen to be higher in Polymyositis/Dermatomyositis patients mainly those with ILD (mean ± SD 38.66 ± 22.98), compared to the control group (Mean ± S 589.04 ± 409) and in patients without ILD (Mean ± SD 86.70 ± 8.99), ( p  
ISSN:2090-3235
1110-161X
2090-3235
DOI:10.1186/s43166-023-00206-9