Preparation and study of modified polyethyleneimine cationic adjuvant

A polyethylenimine adjuvant modified by mannose, which may be used in the study of vaccine adjuvant, was prepared in this paper. Its structure was characterized by infrared spectroscopy and its micromorphology was observed by transmission electron microscopy. A series of mannose-modified polyvinylim...

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Bibliographic Details
Published in:E3S web of conferences 2023-01, Vol.416, p.1008
Main Authors: Bai, Lu, Li, Chengyu, Chen, Xiaoqi, Zhou, Haijun, Zhang, Fen, Cheng, Hua, Li, Yantao, Zhou, Mengmeng
Format: Article
Language:English
Subjects:
adjuvant
cytotoxicity
mannose
polyethyleneimine
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Summary:A polyethylenimine adjuvant modified by mannose, which may be used in the study of vaccine adjuvant, was prepared in this paper. Its structure was characterized by infrared spectroscopy and its micromorphology was observed by transmission electron microscopy. A series of mannose-modified polyvinylimine were prepared according to the molar ratio of primary amine groups between mannose and polyvinylimine, and their storage stability was observed at 4°C. In addition, the cytotoxicity of modified and unmodified polyethylenimine was also tested, and the results showed that the modified polyethylenimine was less toxic than unmodified polyethylenimine.
ISSN:2267-1242
2267-1242
DOI:10.1051/e3sconf/202341601008