Assessment of sestrin 2 as a sepsis marker and predictor of disease severity

Sestrin 2 is considered a stress-inducible antioxidant protein. This study was aimed to evaluate sestrin 2 in subjects with sepsis, and its correlation with clinical severity and mortality. Sepsis and control group patients were followed from admission to discharge. A blood sample was taken at admis...

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Bibliographic Details
Published in:The aging male 2024-12, Vol.27 (1), p.2424300
Main Authors: Baspınar, Osman, Kocer, Derya, Aydın, Kaniye, Dizdar, Oguzhan Sıtkı
Format: Article
Language:English
Subjects:
Aged
Antioxidants
APACHE
Biomarkers
Biomarkers - blood
Blood tests
C-reactive protein
C-Reactive Protein - analysis
Case-Control Studies
Female
Humans
intensive care unit
Male
Medical prognosis
Middle Aged
Mortality
Nuclear Proteins - blood
Predictive Value of Tests
prognosis
Proteins
Sensitivity and Specificity
Sepsis
Sepsis - blood
Sepsis - diagnosis
Sepsis - mortality
sestrin 2
Sestrins
Severity of Illness Index
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Summary:Sestrin 2 is considered a stress-inducible antioxidant protein. This study was aimed to evaluate sestrin 2 in subjects with sepsis, and its correlation with clinical severity and mortality. Sepsis and control group patients were followed from admission to discharge. A blood sample was taken at admission for determination of serum sestrin 2 level. Of the total 42 patients with sepsis, there were 25 females and the mean age was 74.9 years. The sestrin 2 levels were significantly higher in the sepsis group. The optimum sestrin 2 cut-off point of ≥3.13 ng/mL had 95.2% sensitivity and 71.4% specificity for sepsis (  
ISSN:1368-5538
1473-0790
1473-0790
DOI:10.1080/13685538.2024.2424300