Effect of intradialytic extra virgin olive oil-based lipid emulsion on the inflammatory markers TNF alpha, IL1 and IL6 in patients with chronic kidney disease: A randomized clinical trial

• Published in: Journal of functional foods 2024-04, Vol.115, p.106130, Article 106130
• Main Authors: Oliveira, Olvânia Basso, Gaforio Martinez, José Juan, Winkelmann, Eliane Roseli
• Format: Article
• Language: English
• Subjects: Cytokines; Hemodialysis; Inflammation; Lipid emulsion
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2024.106130

•Individuals undergoing hemodialysis are susceptible to inflammation due to the procedure.•An olive oil-based lipid emulsion has an anti-inflammatory effect.•The olive oil-based lipid emulsion is applicable during hemodialysis. The effects of extra virgin olive oil-based lipid emulsion in hemodialysis patients is unclear. The aim of the study was to investigate the effect of an intradialytic extra virgin olive oil-based lipid emulsion administered intravenously on the inflammatory markers tumor necrosis factor alpha (TNF alpha) interleukin I (IL-1) and interleukin 6 (IL-6) in patients undergoing hemodialysis. A randomized clinical trial was conducted using different quantities of the olive oil-based lipid emulsion (0.25 g/kg of body weight, 0.50 g/kg of body weight and control) with a weekly dose for four consecutive weeks. TNF alpha reduced in 51 % of the group that received 0.25 g of the emulsion per kg of body weight and IL1 was reduced in 66 % of the group that received or 0.50 g of the emulsion per kg of body weight. This emulsion is safe, capable of reducing pro-inflammatory markers, thus attenuating the inflammatory response resulting from hemodialysis.