Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study

The aim of the research was to use bioactive heteropolysaccharides isolated from rye bran to obtain innovative systems for the controlled release of bioactive compounds. The core of the obtained encapsulates was honey and royal jelly. It was shown for the first time that preparations effectively ame...

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Bibliographic Details
Published in:Nutrients 2022-06, Vol.14 (12), p.2529
Main Authors: Kowalska, Gabriela, Rosicka-Kaczmarek, Justyna, Mi?kiewicz, Karolina, Zak?os-Szyda, Ma?gorzata, Rohn, Sascha, Kanzler, Clemens, Wiktorska, Magdalena, Niewiarowska, Jolanta
Format: Article
Language:English
Subjects:
Antioxidants
arabinoxylans-based microcapsules
bee products
Bees
Bioactive compounds
bioactive heteropolysaccharides
Bioavailability
Biocompatibility
Biological activity
biostability
Capsules (Pharmacy)
Care and treatment
Cell adhesion & migration
Cell culture
Cell migration
Cellulose
Chemical properties
Controlled release
Cytokines
Digestion
Embryo fibroblasts
Encapsulation
Endothelial cells
Enzymes
Fatty acids
Fibroblasts
Food
Health aspects
Honey
Inflammation
Inflammatory response
Interleukin 6
Lipopolysaccharides
Macrophages
Microvasculature
Nitric oxide
Oxidative stress
Pharmaceutical research
Prebiotics
Proteins
Reagents
Royal jelly
Rye bran
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Wound healing
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Summary:The aim of the research was to use bioactive heteropolysaccharides isolated from rye bran to obtain innovative systems for the controlled release of bioactive compounds. The core of the obtained encapsulates was honey and royal jelly. It was shown for the first time that preparations effectively ameliorated inflammatory response in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages, decreasing the secretion of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and nitric oxide (NO). The in vitro digestion process revealed that bee products’ encapsulates were stronger oxidative stress reducers and had sustained ability to reduction in inflammation state mediators. The lack of inhibitory effect on migration rate of human microvascular endothelial cells (HMEC-1) endothelial cells and mouse embryonic fibroblasts (NIH-3T3), both cell models involved in wound healing process, additionally identified these preparations as agents potentially used in the management of inflammatory response. In the process of a simulated digestion in vitro, the innovative microcapsules showed 85% higher biostability and two to ten times better bioavailability, compared to natural bee products.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14122529