Adipocytes: active facilitators in epithelial ovarian cancer progression?

There is growing evidence that adipocytes play important roles in the progression of multiple cancers. Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflammatory changes of adipose tissue microenvironment, which can further enhance tumor developm...

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Bibliographic Details
Published in:Journal of ovarian research 2020-09, Vol.13 (1), p.1-115, Article 115
Main Authors: Dai, Lan, Song, Keqi, Di, Wen
Format: Article
Language:English
Subjects:
Adipocytes
Adipose tissue
Angiogenesis
Ascites
Cancer metastasis
Cancer progression
Cell adhesion & migration
Cytokines
Development and progression
Drug delivery
Epithelial ovarian cancer
Inflammation
Kinases
Medical prognosis
Metastases
Metastasis
Obesity
Ovarian cancer
Review
Treatment resistance
Tumor necrosis factor-TNF
Tumors
Vascular endothelial growth factor
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Summary:There is growing evidence that adipocytes play important roles in the progression of multiple cancers. Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflammatory changes of adipose tissue microenvironment, which can further enhance tumor development. At present, the roles of adipocytes in the pathogenesis of epithelial ovarian cancer (EOC) are far from being fully elucidated. Herein, we summarized the recent advances in understanding the roles of adipocytes in EOC progression. Adipocytes, close neighbors of EOC tissue, promote EOC growth, invasion, metastasis and angiogenesis through adipokine secretion, metabolic remodeling and immune microenvironment modulation. Moreover, adipocytes are important therapeutic targets and may work as useful anticancer drug delivery depot for EOC treatment. Furthermore, adipocytes also act as a therapeutic obstacle for their involvement in EOC treatment resistance. Hence, better characterization of the adipocytes in EOC microenvironment and the crosstalk between adipocytes and EOC cells may provide insights into EOC progression and suggest novel therapeutic opportunities.
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-020-00718-4