Serum lactates and acute kidney injury in patients with sepsis: A cohort analysis

• Published in: Cogent medicine 2017-01, Vol.4 (1), p.1388209
• Main Authors: Gonçalves, Miguel, Gameiro, Joana, Pereira, Marta, Rodrigues, Natacha, Godinho, Iolanda, Neves, Marta, Gouveia, João, Costa e Silva, Zélia, Jorge, Sofia, Lopes, José António
• Format: Article
• Language: English
• Subjects: acute kidney injury; Cohort analysis; intensive care; Kidney diseases; Kidneys; lactates; Regression analysis; Sepsis
• ISSN: 2331-205X; 2331-205X; 2770-7571
• DOI: 10.1080/2331205X.2017.1388209

Granting the association of lactates with mortality has been largely documented in critically ill patients with sepsis, its association with the development of acute kidney injury (AKI) in this setting is not well established. We aimed to analyze the association of serum lactates at intensive care unit (ICU) admission with the occurrence AKI in a cohort of critically ill septic patients. Materials and methods: This study is retrospective including 457 adult patients with sepsis admitted to the Division of Intensive Medicine of the Centro Hospitalar Lisboa Norte (Lisbon, Portugal) between January 2008 and December 2014. The Kidney Disease Improving Global Outcomes (KDIGO) classification was used to diagnose and classify patients developing AKI within the first week of hospitalization. Logistic regression analysis was employed to determine factors associated with AKI development. Data were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Statistical significance was defined as a p-value