Ageing of skeletal muscle extracellular matrix and mitochondria: finding a potential link

To discuss the progress of extracellular matrix (ECM) characteristics, mitochondrial homeostasis, and their potential crosstalk in the pathogenesis of sarcopenia, a geriatric syndrome characterized by a generalized and progressive reduction in muscle mass, strength, and physical performance. This re...

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Bibliographic Details
Published in:Annals of medicine (Helsinki) 2023, Vol.55 (2), p.2240707-2240707
Main Authors: Cai, Lubing, Shi, Luze, Peng, Zhen, Sun, Yaying, Chen, Jiwu
Format: Article
Language:English
Subjects:
Aged
Ageing
Aging
Extracellular Matrix
Humans
Mitochondria
Muscle, Skeletal
reactive oxygen species
Review
Sarcopenia
Sports Medicine & Musculoskeletal Disorders
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Summary:To discuss the progress of extracellular matrix (ECM) characteristics, mitochondrial homeostasis, and their potential crosstalk in the pathogenesis of sarcopenia, a geriatric syndrome characterized by a generalized and progressive reduction in muscle mass, strength, and physical performance. This review focuses on the anatomy and physiology of skeletal muscle, alterations of ECM and mitochondria during ageing, and the role of the interplay between ECM and mitochondria in the pathogenesis of sarcopenia. Emerging evidence points to a clear interplay between mitochondria and ECM in various tissues and organs. Under the ageing process, the ECM undergoes changes in composition and physical properties that may mediate mitochondrial changes via the systematic metabolism, ROS, SPARC pathway, and AMPK/PGC-1α signalling, which in turn exacerbate muscle degeneration. However, the precise effects of such crosstalk on the pathobiology of ageing, particularly in skeletal muscle, have not yet been fully understood. The changes in skeletal muscle ECM and mitochondria are partially responsible for the worsened muscle function during the ageing process. A deeper understanding of their alterations and interactions in sarcopenic patients can help prevent sarcopenia and improve its prognoses.
ISSN:0785-3890
1365-2060
DOI:10.1080/07853890.2023.2240707