Outcome of lung transplantation in cystic fibrosis patients with severe asymmetric chest cavitiesCentral MessagePerspective

Objective: A small but relevant proportion of patients with cystic fibrosis develop severely asymmetric chest cavities during the course of their disease. For these patients, the best surgical approach for lung transplantation (LTx) and optimal size matching strategies are controversial. Methods: Al...

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Bibliographic Details
Published in:JTCVS open 2021-12, Vol.8, p.652-663
Main Authors: Katharina Sinn, MD, Theresa Stork, MD, Stefan Schwarz, MD, Tomaz Stupnik, MD, Martin Kurz, MD, Peter Jaksch, MD, PhD, Walter Klepetko, MD, Konrad Hoetzenecker, MD, PhD, Gyoergy Lang, MD, PhD, Jose Matilla, MD, Bernhard Moser, MD, PhD, Mir Alireza Hoda, MD, PhD, Shahrokh Taghavi, MD, Edda Tschernko, MD
Format: Article
Language:English
Subjects:
asymmetric chest cavities
cystic fibrosis
lung transplantation
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Summary:Objective: A small but relevant proportion of patients with cystic fibrosis develop severely asymmetric chest cavities during the course of their disease. For these patients, the best surgical approach for lung transplantation (LTx) and optimal size matching strategies are controversial. Methods: All cystic fibrosis patients with asymmetric chest cavities who underwent LTx at the Medical University of Vienna between 2003 and 2017 were identified (n = 13). Patients were grouped according to different surgical strategies: unilateral full-size and contralateral lobar transplantation (n = 4), standard double LTx after mobilization/repositioning of the mediastinum (n = 3), oversized single LTx followed by pneumonectomy on the smaller contralateral side (n = 4), and single LTx after a remote contralateral pneumonectomy (n = 2). Results: Compared with cystic fibrosis patients with symmetric chests (n = 276, control group), the perioperative management of patients with asymmetric chests was often more complicated. Consequently, 90-day mortality was heightened (23.1% vs 6.5%). Despite this, long-term survival was good with a 5-year survival rate of 69% compared with 78%. Of note, outcome seemed superior for patients who surgery was undertaken with a bilateral compared with a unilateral approach. Conclusions: Severely asymmetric chest cavities present challenges in regard to the surgical strategy, size matching, and postoperative management. However, in carefully selected patients, LTx provides an adequate long-term outcome.
ISSN:2666-2736
2666-2736