Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes

Twin studies indicate that 30–40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGS BD ) and clinical- (PGS MDD ) depression summary statistics from the UK Biobank in an independent...

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Bibliographic Details
Published in:Scientific reports 2023-04, Vol.13 (1), p.6534-8, Article 6534
Main Authors: McGeary, John E., Benca-Bachman, Chelsie E., Risner, Victoria A., Beevers, Christopher G., Gibb, Brandon E., Palmer, Rohan H. C.
Format: Article
Language:English
Subjects:
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Anhedonia
Asymmetry
Biobanks
Cognition
Cognition & reasoning
Cognitive ability
Depression - genetics
Depression - psychology
Emotional regulation
Endorsements
Genome-Wide Association Study
Genomes
Genotype & phenotype
Health risk assessment
Hedonic response
Humanities and Social Sciences
Humans
Independent sample
Mental depression
multidisciplinary
Multifactorial Inheritance - genetics
Phenotype
Phenotypes
Polygenic inheritance
Rumination
Schizophrenia
Science
Science (multidisciplinary)
Statistical analysis
Suicidal behavior
Suicidal Ideation
Twin studies
Twins
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Summary:Twin studies indicate that 30–40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGS BD ) and clinical- (PGS MDD ) depression summary statistics from the UK Biobank in an independent sample of adults (N = 210; 100% European Ancestry) who were extensively phenotyped for depression and related neurocognitive traits (e.g., rumination, emotion regulation, anhedonia, and resting frontal alpha asymmetry). The UK Biobank-derived PGS BD had small associations with MDD, depression severity, anhedonia, cognitive reappraisal, brooding, and suicidal ideation but only the association with suicidal ideation remained statistically significant after correcting for multiple comparisons. Similarly small associations were observed for the PGS MDD but none remained significant after correcting for multiple comparisons. These findings provide important initial guidance about the expected effect sizes between current UKB PGSs for depression and depression-related neurocognitive phenotypes.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-33645-7