Positive relationship between number of negative lymph nodes and duration of gallbladder cancer cause-specific survival after surgery

Although the prognostic implications of negative lymph nodes (NLNs) has been reported for a variety of tumors, little information has been published about the NLNs in gallbladder cancer (GBC). In this study, clinicopathological characteristics and survival times of patients who had undergone surgery...

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Bibliographic Details
Published in:Cancer management and research 2018-01, Vol.10, p.6961-6969
Main Authors: Lin, Jin-Yong, Bai, Dou-Sheng, Zhou, Bao-Huan, Chen, Ping, Qian, Jian-Jun, Jin, Sheng-Jie, Jiang, Guo-Qing
Format: Article
Language:English
Subjects:
Cancer
Cancer patients
Cancer research
Care and treatment
Colorectal cancer
Diagnosis
Epidemiology
Gallbladder
Gallbladder cancer
Gastric cancer
Health aspects
Intelligence gathering
Lymph nodes
Lymphatic system
Medical prognosis
Medical research
Metastasis
negative lymph nodes
Original Research
Patients
Prognosis
SEER
Surgery
survival analysis
Tumors
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Summary:Although the prognostic implications of negative lymph nodes (NLNs) has been reported for a variety of tumors, little information has been published about the NLNs in gallbladder cancer (GBC). In this study, clinicopathological characteristics and survival times of patients who had undergone surgery for GBC were collected from the Surveillance, Epidemiology, and End Results Program-registered TNM stage database and analyzed. Univariate and multivariate Cox proportional hazards models were used to identify the predictors of survival. It was found that a cutoff of one to two NLNs is optimal when assessing the association with survival, survival rates being consistently better with two or more NLNs than with fewer than two. This optimal cutoff value of 2 was identified as an independent prognostic factor by univariate and multivariate analyses (all
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S187857