Validation of the ARC-HBR criteria in 68,874 patients undergoing PCI: A systematic review and meta-analysis

The Academic Research Consortium High Bleeding Risk (ARC-HBR) criteria aims to stratify patients undergoing percutaneous coronary intervention (PCI) and are now recommended by international guidelines to stratify bleeding risk in clinical practice. We searched electronic databases from 2019 (ARC-HBR...

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Bibliographic Details
Published in:Hellenic journal of cardiology 2022-07, Vol.66, p.59-66
Main Authors: Montalto, Claudio, Munafò, Andrea Raffaele, Arzuffi, Luca, Casula, Matteo, Mandurino-Mirizzi, Alessandro, Costa, Francesco, Leonardi, Sergio, Oltrona Visconti, Luigi, Ferlini, Marco
Format: Article
Language:English
Subjects:
ARC-HBR
bleeding
High Bleeding Risk
PCI
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Summary:The Academic Research Consortium High Bleeding Risk (ARC-HBR) criteria aims to stratify patients undergoing percutaneous coronary intervention (PCI) and are now recommended by international guidelines to stratify bleeding risk in clinical practice. We searched electronic databases from 2019 (ARC-HBR proposal) up to February 2021 for studies that reported the occurrence of major bleedings according to ARC-HBR status in patients undergoing PCI and pooled them as relative risk (RR) in a random-effect analysis. Only studies that reported events according to the number of times the ARC-HBR definition was met were included in a sensitivity analysis and RR for each stratum was calculated. Nine studies and 68,874 subjects were included in our analysis; 39.2% of them were at HBR and they had a significantly higher risk of major bleedings (RR: 2.70; 95% CI: 2.35–3.10; p 
ISSN:1109-9666
2241-5955
DOI:10.1016/j.hjc.2022.04.008