Targeting human milk fortification to improve very preterm infant growth and brain development: study protocol for Nourish, a single-center randomized, controlled clinical trial

Human milk is recommended for very preterm infants, but its variable macronutrient content may contribute to undernutrition during a critical period in development. We hypothesize that individually targeted human milk fortification is more effective in meeting macronutrient requirements than the cur...

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Bibliographic Details
Published in:BMC pediatrics 2021-04, Vol.21 (1), p.167-167, Article 167
Main Authors: Belfort, Mandy B, Woodward, Lianne J, Cherkerzian, Sara, Pepin, Hunter, Ellard, Deirdre, Steele, Tina, Fusch, Christoph, Grant, P Ellen, Inder, Terrie E
Format: Article
Language:English
Subjects:
Age
Babies
Body composition
Brain
Brain research
Breast milk
Breastfeeding & lactation
Carbohydrates
Care and treatment
Child development
Clinical trials
Composition
Consent
Diet
Dietitians
Energy
Food and nutrition
Growth
Health aspects
Human milk
Infants (Premature)
Intensive care
Intervention
Laboratories
Magnetic resonance imaging
Neonatal care
Neonatal intensive care
Neurodevelopment
Newborn babies
Nutrition
Nutrition research
Pediatric research
Pediatrics
Premature babies
Premature birth
Proteins
Study Protocol
Very preterm infant
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Summary:Human milk is recommended for very preterm infants, but its variable macronutrient content may contribute to undernutrition during a critical period in development. We hypothesize that individually targeted human milk fortification is more effective in meeting macronutrient requirements than the current standard of care. We designed a single-center randomized, controlled trial enrolling 130 infants born
ISSN:1471-2431
1471-2431
DOI:10.1186/s12887-021-02635-x