Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018

We investigated the clinical outcomes and molecular mechanisms of fluconazole-resistant (FR) Candida glabrata bloodstream infections. Among 1,158 isolates collected during multicenter studies in South Korea during 2008–2018, 5.7% were FR. For 64 patients with FR bloodstream infection isolates, the 3...

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Bibliographic Details
Published in:Emerging infectious diseases 2021-03, Vol.27 (3), p.779-788
Main Authors: Won, Eun Jeong, Choi, Min Ji, Kim, Mi-Na, Yong, Dongeun, Lee, Wee Gyo, Uh, Young, Kim, Taek Soo, Byeon, Seung Ah, Lee, Seung Yeob, Kim, Soo Hyun, Shin, Jong Hee
Format: Article
Language:English
Subjects:
Amino acids
Antifungal agents
Antimicrobial agents
Bloodstream Isolates, South Korea, 2008–2018
Candida
Candida glabrata
candidemia
Causes of
Drug resistance in microorganisms
fluconazole resistance
Fluconazole-Resistant
fungal infections
Gene expression
Genetic aspects
Health aspects
Laboratories
Mortality
Mutation
Patient outcomes
PDR1
Septicemia
Survival analysis
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Summary:We investigated the clinical outcomes and molecular mechanisms of fluconazole-resistant (FR) Candida glabrata bloodstream infections. Among 1,158 isolates collected during multicenter studies in South Korea during 2008–2018, 5.7% were FR. For 64 patients with FR bloodstream infection isolates, the 30-day mortality rate was 60.9% and the 90-day mortality rate 78.2%; these rates were significantly higher than in patients with fluconazole-susceptible dose-dependent isolates (30-day mortality rate 36.4%, 90-day mortality rate 43.8%; p
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2703.203482