Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats

We found that curcumin, a p300 histone acetyltransferase (HAT) inhibitor, prevents cardiac hypertrophy and systolic dysfunction at the stage of chronic heart failure in Dahl salt-sensitive rats (DS). It is unclear whether curcumin suppresses the development of hypertension-induced left ventricular h...

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Bibliographic Details
Published in:Nutrients 2021-07, Vol.13 (8), p.2608
Main Authors: Sunagawa, Yoichi, Funamoto, Masafumi, Shimizu, Kana, Shimizu, Satoshi, Sari, Nurmila, Katanasaka, Yasufumi, Miyazaki, Yusuke, Kakeya, Hideaki, Hasegawa, Koji, Morimoto, Tatsuya
Format: Article
Language:English
Subjects:
Acetylation
Age
Blood pressure
Cardiac function
Cardiology
Cardiomyocytes
Congestive heart failure
Curcumin
Ejection fraction
Enzymes
Fibrosis
Heart
Heart enlargement
Heart failure
Histone acetyltransferase
Hypertension
Hypertrophy
Inhibitors
Laboratory animals
LVH
Mortality
Oral administration
p300
Salt
Salts
Software
Transcription
Ventricle
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Summary:We found that curcumin, a p300 histone acetyltransferase (HAT) inhibitor, prevents cardiac hypertrophy and systolic dysfunction at the stage of chronic heart failure in Dahl salt-sensitive rats (DS). It is unclear whether curcumin suppresses the development of hypertension-induced left ventricular hypertrophy (LVH) with a preserved ejection fraction. Therefore, in this study, we randomized DS (n = 16) and Dahl salt-resistant (DR) rats (n = 10) at 6 weeks of age to either curcumin or vehicle groups. These rats were fed a high-salt diet and orally administrated with 50 mg/kg/d curcumin or its vehicle for 6 weeks. Both curcumin and vehicle treatment groups exhibited similar degrees of high-salt diet-induced hypertension in DS rats. Curcumin significantly decreased hypertension-induced increase in posterior wall thickness and LV mass index, without affecting the systolic function. It also significantly reduced hypertension-induced increases in myocardial cell diameter, perivascular fibrosis and transcriptions of the hypertrophy-response gene. Moreover, it significantly attenuated the acetylation levels of GATA4 in the hearts of DS rats. A p300 HAT inhibitor, curcumin, suppresses the development of hypertension-induced LVH, without affecting blood pressure and systolic function. Therefore, curcumin may be used for the prevention of development of LVH in patients with hypertension.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13082608