Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic β-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate β-cell functio...

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Bibliographic Details
Published in:Mediators of Inflammation 2010-01, Vol.2010 (2010), p.542-552
Main Authors: Kaneto, Hideaki, Katakami, Naoto, Matsuhisa, Munehide, Matsuoka, Taka-aki
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Atherosclerosis
Atherosclerosis - metabolism
Atherosclerosis - pathology
Development and progression
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Disease Progression
Glucose - metabolism
Health aspects
Humans
Inflammation
Insulin-Secreting Cells - cytology
Models, Biological
Oxidative Stress
Reactive Oxygen Species
Review
Type 2 diabetes
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Summary:Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic β-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate β-cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.
ISSN:0962-9351
1466-1861
DOI:10.1155/2010/453892